Viral Replicative Capacity Displays a Non-Linear Association to Cytokine Profiles Observed in Acutely Infected Volunteers in Contrast to Viral Load and CD4 T-cell Counts
Viral Replicative Capacity Displays a Non-Linear Association to Cytokine Profiles Observed in Acutely Infected Volunteers in Contrast to Viral Load and CD4 T-cell Counts
Abstract
Using the Meso Scale Discovery (MSD) V-PLEX 40 biomarker cytokine multiplex kit, the cytokine profiles of 108 HIV+ Zambian volunteers were investigated for their associations to virus replicative capacity, CD4 count and viral load. A direct correlation was observed for CD4 count and viral load associated to IP-10 and VCAM-1. Association to virus replicative capacity (vRC) was non-linear for 6 distinct cytokines and subsequent analysis revealed that this relationship was being driven by a small subset of volunteers. Further characterization of these volunteers is ongoing.
Date
Oct 17, 2016
12:00 AM
Event
International AIDS Vaccine Initiative 2016
Location
Chicago